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The diagnosis of disseminated Candida infection is problematic because Candida species are often isolated from mucosal sites in the absence of invasive disease while blood cultures are positive only 50% of the time in disseminated infection Serologic tests have not proved useful for distinguishing colonization from invasive disease Thus, the decision to treat for Candida when organisms are isolated from urine or sputum (or both) needs to be individualized for each patient Disseminated candidiasis may represent a benign, self-limited process, but until proven otherwise it should be considered a sign of serious, complicated disease If fungemia resolves with removal of intravascular catheters, there are often no further complications, but the incidence of endophthalmitis may be higher than previously recognized Other organ system involvement in invasive disease may include the skin, brain, meninges, and myocardium Antifungal therapy for invasive candidiasis is rapidly evolving with the addition of new agents and the emergence of non-albicans species causing significant disease Options for treatment include fluconazole, 400 800 mg daily; amphotericin B, 03 05 mg/kg/d; voriconazole, 200 mg twice a day; caspofungin, 50 mg/d; or micafungin, 100 mg daily Combination therapy with azoles and amphotericin B is an area being explored Flucytosine, 150 mg/kg/d orally in four divided doses, is added if central nervous system involvement occurs Therapy for disseminated candidiasis should be continued for 2 weeks after the last positive blood culture and resolution of symptoms and signs of infection Once patients have become clinically stable, parenteral therapy can be discontinued and oral fluconazole, 200 800 mg orally given as one or two doses daily, is used to complete treatment Although debated, removal or exchange of intravascular catheters is generally recommended and substantially decreases the duration of candidemia and overall mortality, which approaches 30% Another form of invasive disease is hepatosplenic candidiasis This results from aggressive chemotherapy and prolonged neutropenia in patients with underlying hematologic cancers Typically, fever and variable abdominal pain present weeks after chemotherapy, when neutrophil counts have recovered Blood cultures are generally negative Hepatic enzymes reveal an alkaline phosphatase elevation that may be marked Fluconazole, 400 mg daily, or a lipid formulation of amphotericin B is given until clinical and radiographic improvement occurs.



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emboli or from vegetations at the time of valve replacement Valve destruction (usually aortic or mitral) is common, and surgical therapy is necessary in addition to a prolonged course of amphotericin therapy, given in a dosage of 05 1 mg/kg/d intravenously, usually to a total dose of 1 15 g intravenously It is important to note that non-albicans species of Candida now account for over 50% of clinical bloodstream isolates and are often resistant to imidazole antibiotics such as fluconazole The widespread use of these agents for prophylaxis in immunocompromised patients can lead to the emergence of pathogens such as Candida krusei Azole-resistant C albicans has increased in frequency in immunocompromised patients, particularly in patients with late-stage AIDS receiving long-term suppressive fluconazole In all forms of invasive candidiasis, an important element of therapy is reversal of the underlying predisposing factor when possible In high-risk patients undergoing induction chemotherapy, bone marrow transplantation, or liver transplantation, prophylaxis with antifungal agents has been shown to prevent invasive fungal infections although the effect on mortality and the preferred agent remain debated





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Kulberg BJ et al Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial Lancet 2005 Oct 22 28;366(9495):1435 42 [PMID: 16243088] Pappas PG Invasive candidiasis Infect Dis Clin North Am 2006 Sep;20(3):485 506 [PMID: 16984866] Spellberg BJ et al Current treatment strategies for disseminated candidiasis Clin Infect Dis 2006 Jan 15;42(2):244 51 [PMID: 16355336]

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1 Maturity-onset diabetes of the young (MODY) This subgroup is a relatively rare monogenic disorder characterized by non insulin-dependent diabetes with autosomal dominant inheritance and an age at onset of 25 years or younger Patients are nonobese, and their hyperglycemia is due to impaired glucose-induced secretion of insulin Six types of MODY have been described Except for MODY 2, in which a glucokinase gene is defective, all other types involve mutations of a nuclear transcription factor that regulates islet gene expression MODY 2 is quite mild, associated with only slight fasting hyperglycemia and few if any microvascular diabetic complications It generally responds well to hygienic measures or low doses of oral hypoglycemic agents MODY 3 the most common form accounts for two-thirds of all MODY cases The clinical course is similar to that of idiopathic type 2 diabetes in terms of microangiopathy and failure to respond to oral agents with time 2 Diabetes due to mutant insulins This is a very rare subtype of nonobese type 2 diabetes, with no more than ten families having been described Since affected individuals were heterozygous and possessed one normal insulin gene, diabetes was mild, did not appear until middle age, and showed autosomal dominant genetic transmission There is generally no evidence of clinical insulin resistance, and these patients respond well to standard therapy

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JavaScript and jQuery PDF Viewer Plugins — SitePoint
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