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Severe malaria is a medical emergency that ideally should be treated in a monitored setting, due to both the potential rapid progression of complications, even after the initiation of therapy, and to the risk of generation of cardiac arrhythmias by quinine or quinidine Severe malaria can be defined as presentation with any signs of severe illness or organ dysfunction (including prostration, impaired consciousness, convulsions, respiratory distress, shock, acidosis, severe anemia, excessive bleeding, hypoglycemia, jaundice, hemoglobinuria, or renal impairment) or a high parasite load (generally peripheral parasitemia > 5% or > 200,000 parasites/mcL) Indications for parenteral treatment include severe malaria, as defined above, and inability to take oral drugs The cornerstones of treatment of severe malaria are prompt provision of rapidly acting antimalarial therapy and supportive care With appropriate therapy and initial supportive care, rapid recoveries may be seen in even very ill individuals In the developing world, severe malaria and deaths from the disease are mostly in young children, in particular from cerebral malaria, severe anemia, and pulmonary disease In the developed world, mortality from malaria is mostly in adults, and often follows extended illnesses and secondary complications long after eradication of the malarial infection Standard therapy for severe malaria is intravenous quinine In the United States, intravenous quinidine, which is equally effective, is used Patients receiving intravenous quinine or quinidine should receive continuous cardiac monitoring; if QTc prolongation exceeds 25% of baseline, the infusion rate should be reduced Blood glucose should be monitored every 4 6 hours, and 5 10% dextrose may be coadministered to decrease the likelihood of hypoglycemia Fluid management is important;



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Assume that the power system of the previous problem is connected to a resistive Y-connected load of 200 per phase If the internal generated voltage of the generator is E A = 110 20 per unit, what is the terminal voltage of the generator How much power is being supplied to the load SOLUTION The Y-connected load is connected to the end of the transmission line in Region 2, so Z base,2 = 72 , and the per-unit impedance of the load is





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of controlled studies have found the frequency of serious adverse effects from mefloquine to be no higher than that with other common antimalarial chemoprophylactic regimens Nonetheless, mefloquine should be avoided in persons with histories of psychiatric disease or seizures Adverse effects are more common with the higher dosages required for treatment These effects may be lessened by splitting administration of the drug into two doses separated by 6 8 hours The incidence of neuropsychiatric symptoms appears to be about ten times more common than with chemoprophylactic dosing, with widely varying frequencies up to about 50% being reported Serious neuropsychiatric toxicities (depression, confusion, acute psychosis, or seizures) have been reported in less than 1 in 1000 treatments, but some authorities believe that these toxicities are actually more common Mefloquine can also alter cardiac conduction, and so it should not be coadministered with quinine, quinidine, or halofantrine, and caution is required if quinine or quinidine is used to treat malaria after mefloquine chemoprophylaxis Mefloquine is generally considered safe in young children and pregnant women 4 Quinine and quinidine Quinine dihydrochloride and quinidine gluconate remain first-line therapies for falciparum malaria, especially severe disease, although toxicity concerns complicate therapy Quinine is derived from the bark of the cinchona tree, a traditional remedy for intermittent fevers from South America The alkaloid quinine was purified from the bark in 1820, and it has been used in the treatment and prevention of malaria since that time Quinidine, the dextrorotatory stereoisomer of quinine, is at least as effective as parenteral quinine in the treatment of severe falciparum malaria After oral administration, quinine is rapidly absorbed, reaching peak plasma levels in 1 3 hours, with a half-life of about 12 hours Quinidine has a shorter half-life Quinine acts rapidly against the four species of human malaria parasites It is not active against liver stage parasites The mechanism of action of quinine is unknown Increasing in vitro resistance of parasites from a number of areas suggests that quinine resistance will be an increasing problem Resistance is already common in some areas of southeast Asia, where the drug may fail if used alone to treat falciparum malaria However, quinine still provides at least a partial therapeutic effect in most patients Quinine or quinidine is the treatment of choice for severe falciparum malaria Quinine can be administered slowly intravenously or, in a dilute solution, intramuscularly, but parenteral preparations of this drug are not available in the United States, where quinidine is the standard for the parenteral treatment of severe falciparum malaria The drugs can be administered in divided doses or by continuous intravenous infusion; treatment should begin with a loading dose to rapidly achieve effective plasma concentrations Intravenous quinine and quinidine should be administered with cardiac monitoring because of their cardiac toxicity and the relative unpredictability of their pharmacokinetics Therapy should be changed to oral quinine as soon as the patient has improved and can tolerate oral medications In areas without newer combination regimens, oral quinine sulfate is appropriate first-line therapy for uncompli-.

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A JavaScript PDF generation library for Node and the browser. ... You can also read the guide as a self-generated PDF with example output displayed inline.

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