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The best WYSIWYG HTML editor . An impressive Javascript rich text editor with mobile support, complete documentation, many features and inline editing . standard malaria treatment or chemoprophylaxis dosing, even when given for prolonged periods Parenteral administration can result in severe hypotension, and respiratory or cardiac arrest, and this practice should be avoided 2 Amodiaquine Amodiaquine is a 4-aminoquinoline that is closely related to chloroquine, and it probably shares mechanisms of action and resistance with that drug Amodiaquine has been widely used to treat malaria because of its low cost, limited toxicity and, in some areas, effectiveness against chloroquine-resistant strains of P falciparum It was also previously used for chemoprophylaxis Use of amodiaquine decreased after recognition of rare but serious toxicities, notably agranulocytosis, aplastic anemia, and hepatotoxicity However, recent reevaluation has shown that serious toxicity is rare, and it is increasingly advocated as a replacement for chloroquine and in combination regimens (amodiaquine plus sulfadoxinepyrimethamine; amodiaquine plus artesunate; Table 35 3) in areas with high rates of resistance but limited resources Chemoprophylaxis with amodiaquine is best avoided because of its apparent increased toxicity with long-term use 3 Mefloquine Mefloquine is effective therapy for many chloroquine-resistant strains of P falciparum and against other malarial species Although toxicity is a concern, mefloquine is also a commonly recommended chemoprophylactic drug for use in most malaria-endemic regions with chloroquine-resistant parasites Mefloquine is a 4-quinoline methanol that, like chloroquine, has a long half-life, allowing weekly dosing for chemoprophylaxis Resistance to mefloquine has been reported sporadically from many areas At present, resistance appears to be uncommon except in regions of southeast Asia with high rates of multidrug resistance (especially border areas of Thailand and surrounding countries) Mefloquine resistance appears to be associated with resistance to quinine and halofantrine but not with resistance to chloroquine Principal uses of mefloquine are for the treatment and chemoprophylaxis of falciparum malaria For treatment, mefloquine is rapidly active and can be administered as a single dose or in two doses over 1 day It has also been used successfully in combination with artesunate, especially in Thailand where resistance to mefloquine has been seen but the combination remains generally effective Mefloquine should not be used for the treatment of severe malaria because it is relatively slow acting It should be taken with meals and swallowed with a large amount of water For chemoprophylaxis, mefloquine is effective against most strains of P falciparum and probably all other malarial species It is recommended by the CDC for chemoprophylaxis in all malarious areas except for those with no chloroquine resistance (where chloroquine is preferred) and some rural areas of southeast Asia with a high prevalence of mefloquine resistance As with chloroquine, eradication of P vivax and P ovale requires a course of primaquine Adverse effects with weekly dosing with mefloquine for chemoprophylaxis include nausea, vomiting, dizziness, sleep and behavioral disturbances, epigastric pain, diarrhea, abdominal pain, headache, and rash Neuropsychiatric toxicities have received a good deal of publicity, but despite frequent anecdotal reports of seizures and psychosis, a number. pdf javascript editor: How to Add JavaScript Functionality to PDF Forms without Coding ... adobe pdf javascript editor PDF Buddy | Online PDF Editor
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