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A JavaScript PDF generation library for Node and the browser. ... You can also read the guide as a self-generated PDF with example output displayed inline.

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Mycobacterium avium complex (MAC) produces asymptomatic colonization or a wide spectrum of diseases, including coin lesions, bronchitis in patients with chronic lung disease, and invasive pulmonary disease that is often cavitary and occurs in patients with underlying lung disease MAC causes disseminated disease in the late stages of HIV infection, when the CD4 cell count is less than 50/mcL Persistent fever and weight loss are the most common symptoms The organism can usually be cultured from multiple sites, including blood, liver, lymph node, or bone marrow Blood culture is the preferred means of establishing the diagnosis and has a sensitivity of 98% Agents with proved activity against MAC are rifabutin, azithromycin, clarithromycin, and ethambutol Amikacin and ciprofloxacin work in vitro, but clinical results are inconsistent A combination of two or more active agents should be used to prevent rapid emergence of secondary resistance Clarithromycin, 500 mg orally twice daily, plus ethambutol, 15 mg/kg/d orally as a single dose, with or without rifabutin, 300 mg/d orally, is the treatment of choice Azithromycin, 500 mg orally once daily, may be used instead of clarithromycin Insufficient data are available to permit specific recommendations about second-line regimens for patients intolerant of macrolides or those with macrolide-resistant organisms MAC therapy may be discontinued in patients who have been treated with 12 months of therapy for disseminated MAC, who have no evidence of active disease, and whose CD4 counts exceed 100 cells/mcL while receiving highly active antiretroviral therapy (HAART) Antimicrobial prophylaxis of MAC prevents disseminated disease and prolongs survival It is the standard of care to offer it to all HIV-infected patients with CD4 counts 50/mcL In contrast to active infection, single-drug oral regimens of clarithromycin, 500 mg twice daily, azithromycin, 1200 mg once weekly, or rifabutin, 300 mg once daily, are appropriate Clarithromycin or azithromycin is more effective and better tolerated than rifabutin, and therefore preferred Primary prophylaxis for MAC infection can be stopped in patients who have responded to antiretroviral combination therapy with elevation of CD4 counts above 100 cells/mcL for 3 months.



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27 Jul 2018 ... jsPDF doesn't look like it has a way to pack an existing PDF , it just creates brand- new ones. pdfmake and PDFKit also look like they just create ...

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Nocardia asteroides, an aerobic filamentous soil bacterium, causes pulmonary and systemic nocardiosis Bronchopulmonary abnormalities (eg, alveolar proteinosis) predispose to colonization, but infection is unusual unless the patient is also receiving systemic corticosteroids or is otherwise immunosuppressed Pulmonary involvement usually begins with malaise, loss of weight, fever, and night sweats Cough and production of purulent sputum are the chief complaints Radiography may show infiltrates accompanied by pleural effusion The lesions may penetrate to the exterior through the chest wall, invading the ribs Dissemination involves any organ Brain abscesses and subcutaneous nodules are most frequent This is seen exclusively in immunocompromised patients N asteroides is usually found as delicate, branching, grampositive filaments It may be weakly acid-fast, occasionally causing diagnostic confusion with tuberculosis Identification is made by culture For cutaneous infections, therapy is initiated with intravenous trimethoprim-sulfamethoxazole administered at a dosage of 5 10 mg/kg/d (based on trimethoprim) and continued with oral trimethoprim-sulfamethoxazole, one doublestrength tablet twice a day Surgical procedures such as drainage and resection may be needed as adjunctive therapy A higher dose of 15 mg/kg/d (based on trimethoprim) should be used for disseminated or pulmonary infections Imipenem 500 mg intravenously every 6 hours is an alternative Response may be slow, and therapy must be continued for at least 6 months The prognosis in systemic nocardiosis is poor when diagnosis and therapy are delayed Nocardia brasiliensis typically causes a digital lesion resembling herpetic whitlow and ascending lymphangitis in normal hosts Antimicrobial treatment is as for N asteroides infection, and the prognosis is excellent





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Support modification ( editing ) of existing documents. Work in all ... There are other good open source JavaScript PDF libraries available. However, most of them ...

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Brown-Elliott BA et al Clinical and laboratory features of the Nocardia spp based on current molecular taxonomy Clin Microbiol Rev 2006;19:259 282 [PMID: 16614249]

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MAC causes a chronic, slowly progressive pulmonary infection resembling tuberculosis in immunocompetent patients, who typically have underlying pulmonary disease Treatment of immunocompetent patients with pulmonary infection is empiric and based entirely on anecdotal data A combination of agents is probably best Rifampin, 600 mg orally once daily, plus ethambutol, 15 25 mg/kg/d orally, plus streptomycin, 1 g intramuscularly three to five times a week for the first 4 6 months, have been used The role of rifabutin,

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About 10% of mycobacterial infections are caused by atypical mycobacteria Atypical mycobacterial infections are among

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A next generation WYSIWYG JavaScript Word Processor with robust editing and formatting capabilities that helps you create powerful word documents.

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fluoroquinolones, and the macrolides is not known, but based on their excellent efficacy in immunocompromised AIDS patients, they may actually be more effective than the relatively weak agents traditionally used in immunocompetent patients Clarithromycin is a very potent drug in the treatment of MAC in AIDS patients Based on this, inclusion of clarithromycin in the initial treatment regimen of immunocompetent patients is prudent Therapy is continued for a total of 18 24 months Mycobacterium kansasii can produce clinical disease resembling tuberculosis, but the illness progresses more slowly Most such infections occur in patients with preexisting lung disease, though 40% of patients have no known pulmonary disease Microbiologically, M kansasii is similar to Mycobacterium tuberculosis and is sensitive to the same drugs except pyrazinamide, to which it is resistant Therapy with isoniazid, ethambutol, and rifampin for 2 years (or 1 year after sputum conversion) has been successful Less common causes of pulmonary disease include Mycobacterium xenopi, Mycobacterium szulgai, and Mycobacterium gordonae These organisms have variable sensitivities, and treatment is based on results of sensitivity tests Mycobacterium fortuitum and Mycobacterium chelonei also can cause pneumonia in the occasional patient

Mycobacterium ulcerans infection (Buruli ulcer) is seen mainly in Africa and Australia and produces a large ulcerative lesion Therapy consists of surgical excision and skin grafting

Shitrit D et al Pulmonary Mycobacterium kansasii infection in Israel, 1999 2004: clinical features, drug susceptibility, and outcome Chest 2006 Mar;129(3):771 6 [PMID: 16537880]

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11 Jan 2012 ... The Javascript Console can be used to add JavaScript to documents in PDF - XChange Editor . JavaScript is a high-level programming language that can be used to perform a range of operations.












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