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advocacy of new combination regimens as first-line therapies Most of these regimens are combinations of highly potent but short-acting artemisinin derivatives with longer-acting partner drugs The World Health Organization (WHO) currently lists five combination therapies as desirable treatments for falciparum malaria in most areas (Table 35 3), but recent reports show that the efficacy of these five regimens varies Other combination therapies are under development, and it is likely that choices of optimal regimens will change in the near future Another regimen that remains generally effective for falciparum malaria is quinine, but this drug must be taken for an extended period to cure disease and is quite poorly tolerated Thus, in the developing world quinine is generally reserved for the treatment of severe malaria and, in some instances, for treatment after another regimen has failed In developed countries, malaria is an uncommon but potentially life-threatening infection of travelers and immigrants, many of whom are nonimmune, so they are at risk for rapid progression to severe disease Nonimmune individuals with falciparum malaria should generally be admitted to the hospital due to risks of rapid progression of disease Therapeutic decisions are not limited by cost, but newer drugs are not available in some countries For example, new artemisinin derivatives are not approved in the United States, where none of the current WHO recommended regimens for falciparum malaria are available With these limitations, treatment of malaria in the United States is straightforward (Table 35 4)



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Regimen Artemether-lumefantrine (Coartem, Riamet) Artesunate-amodiaquine (ASAQ) Artesunate-mefloquine Artesunate-sulfadoxinepyrimethamine Amodiaquine-sulfadoxinepyrimethamine Notes Coformulated, first-line therapy in multiple African countries Coformulated, first-line therapy in multiple African countries Standard therapy in parts of southeast Asia Efficacy low compared with other regimens in some areas Less expensive; efficacy varies, but remains good in some areas; recommended as an interim option when efficacy established and other regimens are not available

The resulting per-phase equivalent circuit is:

World Health Organization: Guidelines for the Treatment of Malaria World Health Organization Geneva 2006 ISBM 924 1546948

this combination antifolate regimen is slower acting than most other agents, and suffers from increasing resistance in most areas Antimalarial therapy in the developing world has undergone major change in recent years, with increasing





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Clinical Setting Chloroquine-sensitive Plasmodium falciparum and Plasmodium malariae infections Plasmodium vivax and Plasmodium ovale infections Uncomplicated infections with chloroquine-resistant P falciparum Drug Therapy1 Chloroquine phosphate, 1 g, followed by 500 mg at 6, 24, and 48 hours or Chloroquine phosphate, 1 g at 0 and 24 hours, then 05 g at 48 hours Chloroquine (as above), then (if G6PD normal) primaquine, 30 mg base daily for 14 days Quinine sulfate, 650 mg three times daily for 3 7 days Plus one of the following Doxycycline, 100 mg twice daily for 7 days or Clindamycin, 600 mg twice daily for 7 days or Fansidar, three tablets once Severe or complicated infections with P falciparum 3 Quinidine gluconate,2,3 10 mg/kg IV over 1 2 hours, then 002 mg/kg IV/min or 15 mg/kg IV over 4 hours, then 75 mg/kg IV over 4 hours every 8 hours Malarone, 4 tablets (total of 1 g atovaquone, 400 mg proguanil) daily for 3 days or Mefloquine, 15 mg /kg once or 750 mg, then 500 mg in 6 8 hours or Artesunate or artemether, single daily doses of 4 mg/kg on day 0, 2 mg/kg on days 2 and 3, 1 mg/kg on days 4 7 or Coartem (artemether 20 mg, lumefantrine 120 mg), four tablets twice daily for 3 days Artesunate,3 24 mg/kg IV or IM, then 12 mg/kg every 12 hours for 1 day, then every day or Artemether,3 32 mg/kg IM, then 16 mg/kg/d IM Alternative Drugs

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1 All dosages are oral and refer to salts unless otherwise indicated See text for additional information on all agents, including toxicities and cautions See Centers for Disease Control and Prevention s guidelines (phone: 877-FYI-TRIP; http://wwwcdcgov) for additional information and pediatric dosing 2 Cardiac monitoring should be in place during intravenous administration of quinidine 3 With all parenteral regimens, change to an oral regimen as soon as the patient can tolerate it G6PD, glucose-6-phosphate dehydrogenase Reproduced, with permission, from Katzung BG Basic & Clinical Pharmacology 10th edition McGraw-Hill, 2007

Falciparum malaria from areas without known resistance should be treated with chloroquine Falciparum malaria from most areas is best treated with oral quinine or intravenous quinidine, in either case plus doxycycline or, for children, clindamycin Other agents that are generally effective against resistant falciparum malaria include mefloquine and halofantrine, both of which have toxicity concerns at treatment dosages, atovaquone/proguanil (Malarone), and the artemisinin derivatives artesunate and artemether (alone or in combination, as discussed below)

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