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the latter case, a liquid phase may coat the particle and be attached by noncovalent, physical attraction. This type of system is called liquid liquid phase chromatography. A good example of liquid liquid phase chromatography is silica coated with a nonpolar hydrocarbon (e.g. C-18 reverse phase chromatography; Section 2.4.3). Commonly, the particles are composed of hydrated polymers such as cellulose or agarose. Such particles may be immobilized in a column (Section 2.3.1) and washed with mobile phase. They offer good ow characteristics and possess suf cient mechanical strength and chemical inertness for the chromatography of biomolecules. Because biomolecules have evolved to function in an aqueous environment, it is usually necessary to use aqueous buffers as the mobile phase if we require the molecule to retain its native structure (e.g. in the puri cation of active enzymes). If the native structure is not required, however, then it is possible to use more nonbiological conditions such as organic solvents (e.g. in puri cation of peptides by reverse phase chromatography; Section 2.4.3). Liquid solid or liquid liquid phases are the most common phase systems used in biochemistry. However, in specialized situations other phases may be used. For example, gas-solid and gas-liquid phases are used in gas chromatography (GC; Section 2.1.4). Regardless of the precise phase composition, chromatographic separation is a direct result of the different K values of each sample component. 2.1.3



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Keep reading on the aforementioned page; you ll see an example of a bogus security bulletin that was used to distribute the Swen worm back in 2003. Very scary!

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Several approaches were used to model risks quantitatively. The models generated quantitative measures of the level of risk associated with the main options for mine waste management. Results were presented in a variety of ways for the board and other stakeholders, in a way that provided as much information as possible and demonstrated the variability in the outcomes. The aim was to provide results that could be understood readily, without either over-simplifying or over-complicating them. Figure 18.14 shows an example from an early run of the model, demonstrating that the Dredge option has the lowest risk cost at any specified level of confidence. Figure 18.15 shows another representation of the costs of the risks that might arise with each option, compared with their fixed or base costs, using different methods for analysing and estimating risk. As noted earlier, the OTML Board was concerned to ensure the risk management was adequate and transparent, and could be justified to the wide range of key stakeholders. The overall process provided outcomes that were valuable for the board, management and shareholders in determining the most appropriate course of action, given the complexity and constraints in the operating environment. The audit report confirmed this. More details are provided on the Ok Tedi website, www.OkTedi.com (search for risk), and in Bowden, Lane and Martin (2001).

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Figure 9.4 Effect of age on the excess all-cause mortality conferred by a 1-kg/m2 increment in BMI, in men and women. Data from the Cancer Prevention Study (Stevens, 1992a,b).

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(b) The rearrangement of Dewar benzene to benzene:

The underlying motivation to establish traceability and MU is the need to make decisions based on the obtained analytical results or to be in compliance with regulatory limits (for quantitative determinations) [51] MU is an essential feature of analytical results for different reasons First, customers want to have an idea about the dispersion of results and about the comparability of results between different laboratories [43] Any result must be accompanied by a statement of MU, so that the user of the result knows what level of con dence is associated with it [52] The concepts of comparability and reliability of results have been discussed brie y in Section 821 and are presented in Figure 1 Second, MU is necessary because it demonstrates traceability Before MU can be evaluated, traceability to stated references or standards must be established Moser et al.

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