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1 US Pharmacopeia (USP), Stability considerations in dispensing practice, USP 29/NF 24, USP, Rockville, MD, p 3029 2 Guillory, P, and Poust, R (2002), Chemical kinetics and drug stability, in Banker and Rhodes, Eds, Drugs in the Pharmaceutical Sciences, Vol 121, Marcel Dekker, New York, pp 139 166 3 Lintner, C C (1973), Quality Control in the Pharmaceutical Industry, Vol 2, Academic, New York, p 141 4 Connors, K A, Amidon, G L, and Stella, J V (1986), Chemical Stability of Pharmaceuticals, 2nd ed, Wiley, New York 5 McMinn, C S, and Lintner, C J (1973, May), paper presented at the American Pharmaceutical Association Academy of Pharmaceutical Sciences Meeting, Pharmaceutical Technical Section, Chicago, IL 6 Lachman, L, DeLuca, P, and Akers, J J (1986), Kinetic principles and stability testing, in Lachman, L, Lieberman, H A, and Kanig, J L.

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, Eds, The Theory and Practice of Industrial Pharmacy, 3rd ed, Lea & Febiger, Philadelphia, p 766 7 Fung, H-L, and King, S-Y (1983), in Pharmaceutical Technology Conference 83 Proceedings, Aster Publishing, Spring eld, OR 8 Pikal, M J, Lukes, A L, and Lang, J E (1977), J Pharm Sci, 66, 1312 9 Woolfe, J, and Worthington, H E C (1974), Drug Dev Commun, 1, 185 10 Wang, W (1999), Instability, stabilization, and dormulation of liquid protein pharmaceuticals, International Journal of Pharmaceutics, 185, 129 188 11 Gu, LC, Erdos, E A, Chang, H-S (1991), Pharm Res 8, 485 12 (a) Center for Drugs and Biologics, US Food and Drug Administration (FDA) (1987, Feb), Guideline for submitting documentation for the stability of human drugs and Biologics, FDA, Rockville, MD.

(b) Center for Drug Evaluation and Research and Center for Biologics Evaluation and Research, US Department of Health and Human Services, FDA (1998, June), Guidance for industry: Stability testing of drug substances and drug products: Draft guidance, FDA, Rockville, MD 13 US Pharmacopeia (USP), Pharmaceutical stability, USP 29/ NF 24, USP, Rockville, MD p 2994 14 Hansch, A L, and Taft, R E (1991), A survey of Hammett substituent constants and resonance and eld parameters, Chem Rev, 91, 165 15 Hammett, L P (1970), Physical Organic Chemistry, 2nd ed, McGraw-Hill, New York 16 Johnson, D M, and Gu, L C (1998), Autooxidation and antioxidants, in Swarbrick, J, and Boylan, J C Eds, Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York, pp 415 449 17 Vadas, E B.

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(2000), Stability of pharmaceutical products, in Remington: The Science and Practice of Pharmacy, 20th ed, Lippincott Williams and Wilkins, Baltimore, MD, p 989 18 Ogata, M, Noro, Y, Yamada, M, Tahara, T, and Nishimura, T (2000), Photo-degradation products of methylprednisolone sulphanate in aqueous solution Evidence of a bicyclo[310]hex-3-en-2-one intermediate, J Pharm Sci, 87(1), 91 95 19 Hauser, U, Oestreich, V, and Rohrweck, H D (1977), On optical dispersion in transparent molecular systems, Zeits Phys A, 280, pp 17 25..

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PART considers heterogeneities in both the application and the system. In particular, PART takes into consideration that different mesh-based applications may have different computational complexities and the mesh may consist of different element types. For distributed systems, PART takes into consideration heterogeneities in processor and network performance. Figure 16.4 shows a ow diagram of PART. PART consists of an interface program and a simulated annealing program. A nite element mesh is fed into the interface program and produces the proposed communication graph, which is then fed into a simulated annealing program where the nal partitioning is computed. This partitioned graph is translated to the required input le format for the application. This section describes the interface program and the steps required to partition the graph.

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